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The First in Human trial of Rincell-1 - SnackShaman - November 18, 2025
Rinri Therapeutics is starting a first-in-human trial of Rincell‑1, a cell therapy made from otic neural progenitors that can develop into auditory neurons to treat neural hearing loss. The therapy is delivered directly into the cochlea during cochlear implant surgery, with participants split between receiving just the implant or the implant plus Rincell‑1, to assess both safety and effects on neural health. The trial is being conducted in partnership with NHS cochlear implant centers in the UK and has regulatory approval. Participants will be followed for 13 months, with regular health and hearing checks, and daily measurements from their implants recorded on a tablet. In addition, Rinri has conducted studies using cochlear implant electrodes to record neural signals, helping validate objective ways to measure auditory neuron health for future trials.
https://clinicaltrials.gov/study/NCT07032038
https://www.rinri-therapeutics.com/our-clinical-research/#rincell
Anyone excited about this? Anyone considering signing up for the trial?
RE: The First in Human trial of Rincell-1 - CortexShadow - January 7, 2026
Interesting This is trying to actually regrow auditory neurons, and that is something no current treatment really does. The trial is only open to adults approved for cochlear implants through the NHS in the UK and is currently listed on ClinicalTrials.gov as Not yet recruiting. So it is still in the early setup phase rather than actively enrolling right now.
It sounds exciting in theory, but it is easy to get your hopes up, this is a very early first‑in‑human study and we do not yet know if the injected cells will survive, integrate, or meaningfully improve hearing. There is definite potential here, but I would keep expectations realistic because many things that look good in the lab do not always pan out in people. If it works it could be a big step forward, but there are still plenty of unknowns before this becomes a reliable solution