November 25, 2025, 08:52 PM
![[Image: m_fcaa131f4.jpeg?Expires=1765921654&Sign...RDK6RD3PGA]](https://oup.silverchair-cdn.com/oup/backfile/Content_public/Journal/braincomms/2/2/10.1093_braincomms_fcaa131/1/m_fcaa131f4.jpeg?Expires=1765921654&Signature=nTKeiNv6Ntxkj4JqrHdZABpTfmiuuj-UAFYAJYvau543UaJ6Kpzps85jj807BZJpyO5IRWXBMPiQVZcSVBtOArH-kK8-dDS0mtXlXeXt3JmzwqXaIkPsU2Fqs5ATKHlcRfF5uShhJrvitVbW3j6Tp1-qoss3-0r9gE97eQ6vSyJ2V4hJGiC7S4fOV97WrEP~dCHrc1-u8jiEAjReFsT10AaOxYRrboVTBXexcsUpRR9eyzRdp3-RKDylkLPZkJuPQQRXbtyi-YD3YvIF15nlhgUgwJYuoy3JRFxxzJObjvsVoVf38up6gi1BqA91Rj7z9FZ2YaNIYpBYJwG3N-~yug__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
The effects of sound therapy in tinnitus are characterized by altered limbic and auditory networks.
- The study examined the effects of 12 weeks of individualized sound therapy on 30 tinnitus patients with normal hearing, compared to healthy controls.
- Resting-state fMRI measured local brain activity (ALFF) and functional connectivity before and after therapy.
- Before therapy, patients had elevated activity in the left parahippocampal gyrus, which decreased after therapy toward normal levels.
- Activity in the right Heschl’s gyrus (primary auditory cortex) increased after therapy.
- Functional connectivity between the parahippocampal gyrus and limbic regions strengthened after therapy, indicating altered brain network interactions.
- Changes in brain activity and connectivity correlated with reductions in tinnitus symptoms.
Key takeaway: Sound therapy reduces tinnitus by reshaping brain activity and connectivity in auditory and emotional networks, not just masking the sound.