November 18, 2025, 08:12 AM
Rinri Therapeutics is starting a first-in-human trial of Rincell‑1, a cell therapy made from otic neural progenitors that can develop into auditory neurons to treat neural hearing loss. The therapy is delivered directly into the cochlea during cochlear implant surgery, with participants split between receiving just the implant or the implant plus Rincell‑1, to assess both safety and effects on neural health. The trial is being conducted in partnership with NHS cochlear implant centers in the UK and has regulatory approval. Participants will be followed for 13 months, with regular health and hearing checks, and daily measurements from their implants recorded on a tablet. In addition, Rinri has conducted studies using cochlear implant electrodes to record neural signals, helping validate objective ways to measure auditory neuron health for future trials.
https://clinicaltrials.gov/study/NCT07032038
https://www.rinri-therapeutics.com/our-c...h/#rincell
Anyone excited about this? Anyone considering signing up for the trial?